A 66-YEAR-OLD woman died of total organ failure after she developed profound electrolyte abnormalities on a background of severe vomiting whilst taking Ozempic for weight loss and Metformin to control her diabetes, an inquest in Cork has heard.
Breeda O’Donoghue of West End in Carrigtwohill, Co Cork died on 9 December, 2023 at Cork University Hospital (CUH) having been hospitalised three days earlier. A family member told Cork Coroner’s Court that Breeda was “fine” and in “good health” until she took Ozempic in a bid to lose weight.
Coroner Philip Comyn heard that Mrs O’Donoghue joined the surgery of Dr Sushil Ranga in Carrigtwohill in early 2017 after she moved to the area. In a report read in to the record Dr Ranga said that the deceased was a diagnosed Type two diabetic. Breeda also had osetoathritis, restless legs and hypertension.
Dr Ranga said that Mrs O’Donoghue had commenced on diabetes drug Metformin after she was prescribed it by her GP in Youghal in 2016.
“She was seen on a regular basis and monitored along with blood test etc. Her diabetes was very well controlled at this point on medication and diet so she did not require endocrinology.”
In 2020 Mrs O’Donoghue had a flare up of her osteoarthritis. Over time her pain settled but she started to gain weight.
Dr Ranga said that Mrs O’Donoghue was struggling to lose weight via diet in exercise and was “very self conscious.”
Dr Ranga said that in 2023 Mrs O’Donoghue, who was 5ft 3 inches in height, had a BMI of 35.94. Dr Ranga said that Breeda was 92KG.
“She was reviewed and had blood tests and her diabetes was controlled, but she was unable to lose weight. So per protocol, she was started on Ozempic 0.25mg on 19/09/23 and after four weeks the dose was increased to 0.5mg on 19/10/23.
She was reviewed on 26/10/23 and her weight had reduced to 85.7kg (13 stone and 6.94 pounds) and her BMI was now 33.4. She was very happy and managing well and denied any problems.”
Dr Ranga said that on 26 October, 2023 the dose of Ozempic was increased to 1.0mg.
“She (Mrs O’Donoghue) was again reviewed on 07/11/23 and was very happy with the results, denying any problems and said that she was tolerating the medication well.
On 23/11/23, she reported nausea only, but was drinking plenty fluids and was eating ok, so she was prescribed anti-nausea medication and advised to review after a week. After one week, she was still suffering from nausea, so she was advised to stop Ozempic and review.
But she was not keen to attend, so she stated that she would attend at a later date if she did not improve.
Her husband rang on 06/12/23 reporting that she was not well, so I immediately reviewed her in clinic. On examination she was feeling weak, dehydrated and was generally unwell, so she was immediately sent to A and E via ambulance for further hospital management.”
Dr Ranga said that Mrs O’Donoghue has been using Metformin since 2016 and reported “no issues.”
The inquest hea
Femeia a murit din cauza insuficienței organelor în timp ce lua Ozempic și un medicament pentru diabet, a aflat ancheta

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